East Sussex - Better Together
NHS

4.9.1 Dopaminergic drugs used in Parkinson's disease

Sudden onset of sleep: Excessive daytime sleepiness and sudden onset of sleep can occur with co-careldopa, co-beneldopa, and the dopamine receptor agonists.  Patients starting on treatment with these drugs should be warned of the possibility of these effects and of the need to exercise caution when driving or operating machinery.  Patients who have suffered excessive sedation or sudden onset of sleep, should refrain from driving or operating machines, until those effects have stopped

All initiations must take place in secondary care under the direct supervision of the Parkinsons' specialist nurse

Patients must be stabilised on domperidone for at least two days before starting apormorphine treatment

Pack
5 ampoule

For intermittent subcutaneous injection

Pack
5 pre-filled disposable injection

For continuous subcutaneous infusion in the community

Pack
5 pre-filled disposable injection
Pack
5 ampoule
Pack
90 tablet

Sinemet Plus equivalent

Pack
100 tablet
Pack
100 tablet

Half Sinemet CR equivalent

Pack
100 tablet

Sinimet CR equivalent

Pack
60 tablet

For second line use if entacapone is not tolerated

Pack
30 capsule
Pack
56 tablet
Pack
28 tablet

1.25mg of selegiline oral lyophilisate is approximately therapeutically equivalent to 10mg selegiline tablets

Pack
30 tablet
Pack
200 ml

Tolcapone is associated with potentially life-threatening hepatotoxicity hence regular monitoring of liver function is necessary

Pack
100 tablet
  • First Line Drugs
  • Second Line Drugs
  • Specialist Initiated Drugs
  • Specialist Only Drugs
  • Mixed Status