10.1.1 Non-steroidal anti-inflammatory drugs
Differences in anti-inflammatory activity between different NSAIDs are small; pain relief starts soon after taking the first dose and full analgesia is normally obtained within one week; anti-inflammatory effects may take 3 weeks to achieve. If an inadequate response is obtained within these time intervals, a different NSAID should be tried.
When used at high doses for long-term treatment, non-selective NSAIDs may also be associated with a small increased risk of thrombotic events. Diclofenac is associated with a higher risk than naproxen. There may be a small risk with high doses of ibuprofen (2.4g daily) but lower doses (1.2g daily or less) are not associated with an increased risk.
Related guidance:
NICE NG73: Endometriosis: diagnosis and management
NICE NG148: Acute kidney injury - prevention, detection and management
Smaller pack sizes are available OTC
| Pack |
|---|
| 100 tablet |
| Pack |
|---|
| 100 tablet |
| Pack |
|---|
| 100 ml |
MHRA Safety Update: Diclofenac: new contraindications and warnings
| Pack |
|---|
| 84 tablet |
| Pack |
|---|
| 84 tablet |
| Pack |
|---|
| 56 capsule |
| Pack |
|---|
| 28 capsule |
| Pack |
|---|
| 21 tablet |
Diclofenac suppositories are preferred to diclofenac injection (which may be painful when given IM) for the acute relief of pain e.g. biliary colic.
| Pack |
|---|
| 10 suppository |
Diclofenac suppositories are preferred to diclofenac injection (which may be painful when given IM) for the acute relief of pain e.g. biliary colic.
| Pack |
|---|
| 10 suppository |
Diclofenac suppositories are preferred to diclofenac injection (which may be painful when given IM) for the acute relief of pain e.g. biliary colic.
| Pack |
|---|
| 10 suppository |
Diclofenac suppositories are preferred to diclofenac injection (which may be painful when given IM) for the acute relief of pain e.g. biliary colic.
| Pack |
|---|
| 10 suppository |
| Pack |
|---|
| 10 ampoule |
| Pack |
|---|
| 5 ampoule |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
- First Line Drugs
- Second Line Drugs
- Specialist Initiated or Recommended Drugs
- Specialist Initiated Drugs with Shared Care Guidelines
- Specialist Only Drugs
- Mixed Status