Lipid regulating drugs
|
|
Reduction in Low density lipoprotein cholesterol |
||||
|
Dose (mg/day) |
5 |
10 |
20 |
40 |
80 |
|
Fluvastatin |
- |
- |
21%1 |
27%1 |
33%2 |
|
Pravastatin |
- |
20%1 |
24%1 |
29%1 |
- |
|
Simvastatin |
- |
27%1 |
32%2 |
37%2 |
42%3,4 |
|
Atorvastatin |
- |
37%2 |
43%3 |
49%3 |
55%3 |
|
Rosuvastatin |
38%2 |
43%3 |
48%3 |
53%3 |
- |
|
1 20% - 30%: low intensity 2 31% - 40%: medium intensity 3 above 40%: high intensity 4 Advice from the MHRA: there is an increased risk of myopathy associated with high-dose (80 mg) simvastatin. The 80 mg dose should be considered only in patients with severe hypercholesterolaemia and high risk of cardiovascular complications who have not achieved their treatment goals on lower doses, when the benefits are expected to outweigh the potential risks. |
|||||
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 1 pre-filled disposable injection |
Capsules may be opened for patients with swallowing difficulties
| Pack |
|---|
| 28 capsule |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 90 tablet |
| Pack |
|---|
| 28 capsule |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 98 tablet |
| Pack |
|---|
| 28 capsule |
| Pack |
|---|
| 28 tablet |
| 30 tablet |
| 98 tablet |
| Pack |
|---|
| 28 capsule |
| Pack |
|---|
| 28 tablet |
MHRA Drug Safety Update: Simvastatin: updated advice on drug interactions
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 28 tablet |
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
| Pack |
|---|
| 2 pre-filled disposable injection |
| Pack |
|---|
| 1 pre-filled disposable injection |
- First Line Drugs
- Second Line Drugs
- Specialist Initiated or Recommended Drugs
- Specialist Initiated Drugs with Shared Care Guidelines
- Specialist Only Drugs
- Mixed Status