3.8 Allergic Emergencies

Dose of intramuscular injection of adrenaline (epinephrine) for anaphylactic shock.



Volume of adrenaline

1 in 1000 (1mg / ml)

Dose of auto-injector

Under 6 years

150 micrograms


150 microgram

6-12 years

300 micrograms

0.3 ml

300 microgram

Adult and adolescent

500 micrograms

0.5 ml

300 or 500 microgram

Based on advice from the Resuscitation Council (UK).

Patients should be advised to:

  • contact emergency services after the first injection
  • use the second auto-injector 5–15 minutes after the first one if they do not start to feel better

Prescribe adrenaline auto-injectors by the brand name as different brands have different administration techniques

Please see MHRA guidance which advises that patients should carry TWO auto-injectors at all times

Patients may need two auto-injectors at different locations such as school and home

Replace like for like as and when they expire/ are used

 Related NICE guidance:

NICE CG134 Anaphylaxis: assessment and referral after emergency treatment

TA 246 (Feb 2012) Pharmalgen® for bee and wasp venom allergy

Antihistamines can be found in chapter 12 – ENT

CCG commissions for chronic spontaeous urticaria only - please complete blueteq form. NHS England commissions for all other indications

1 vial
1 pre-filled disposable injection
  • First Line Drugs
  • Second Line Drugs
  • Specialist Initiated Drugs
  • Specialist Only Drugs
  • Mixed Status